Retinoic acid receptor
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| retinoic acid receptor, alpha
| |
| Identifiers | |
| Symbol(s) | RARA |
| Entrez | 5914 |
| OMIM | 180240 |
| RefSeq | NM_000964 |
| UniProt | P10276 |
| Other data | |
| Locus | Chr. 17 q12 |
| retinoic acid receptor, beta
| |
| Identifiers | |
| Symbol(s) | RARB |
| Entrez | 5915 |
| OMIM | 180220 |
| RefSeq | NM_000965 |
| UniProt | P10826 |
| Other data | |
| Locus | Chr. 3 p24 |
| retinoic acid receptor, gamma
| |
| Identifiers | |
| Symbol(s) | RARG |
| Entrez | 5916 |
| OMIM | 180190 |
| RefSeq | NM_000966 |
| UniProt | P13631 |
| Other data | |
| Locus | Chr. 12 q13 |
There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma. Each receptor isoform has several splice variants: two- for alpha, four- for beta and two- for gamma. The RAR's are nuclear receptors with activity similar to the steroid receptors such as estrogen or progesterone and other nuclear receptors: PPAR, LXR and FXR. All-trans retinoic acid is the natural ligand for RAR. Like the steroid receptors, when activated, RARs dimerize usually forming heterodimers, translocate to the cell nucleus, and bind to RAR response elements on DNA, which elicits expression or transrepression of gene products. 9-cis retinoic acid is the natural ligand of another nuclear hormone receptor termed the retinoid x receptor.
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