Retrovirus

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iRetroviruses

Virus classification

Group:	Group VI (ssRNA-RT)
Family:	Retroviridae

Genera

Alpharetrovirus
Betaretrovirus
Gammaretrovirus
Deltaretrovirus
Epsilonretrovirus
Lentivirus
Spumavirus

A retrovirus is any virus belonging to the viral family Retroviridae. They are enveloped viruses possessing an RNA genome, and replicate via a DNA intermediate. Retroviruses rely on the enzyme reverse transcriptase to perform the reverse transcription of its genome from RNA into DNA, which can then be integrated into the host's genome with an integrase enzyme.

1 Description of virus
2 Reproduction
3 In Fiction
4 See also
5 External links

[edit] Description of virus

The virus itself stores its nucleic acid genome and serves as a means of delivery of that genome into cells it targets as an obligate parasite, and constitute the infection. Once in the host's cell, the RNA strands undergo reverse transcription in the cytosol and are integrated into the host's genome, at which point the retroviral DNA is referred to as a provirus.

[edit] Reproduction

When retroviruses have integrated their genome into the germ line, their genome is passed on to a following generation. These endogenous retroviruses, contrasted with exogenous ones, now make up 8% of the human genome. Most insertions have no known function and are often referred to as "junk DNA". However, many endogenous retroviruses play important roles in host biology, such as control of gene transcription, cell fusion during placental development in the course of the germination of an embryo, and resistance to exogenous retroviral infection. Endogenous retroviruses have also received special attention in the research of immunology-related pathologies, such as autoimmune diseases such as multiple sclerosis, although endogenous retroviruses have not yet been proven to play any causal role in this class of disease. The role of endogenous retroviruses in human gene evolution is explored in a recent peer-reviewed article. abstract.

While transcription was classically thought to only occur from DNA to RNA, reverse transcriptase transcribes RNA into DNA. The term "retro" in retrovirus refers to this reversal (making DNA from RNA) of the central dogma of molecular biology. Reverse transcriptase activity outside of retroviruses has been found in almost all eukaryotes, enabling the generation and insertion of new copies of retrotransposons into the host genome. It is important to note that a retrovirus must "bring" its own reverse transcriptase in its capsid, otherwise it is unable to utilize the infected cell's enzymes to carry out the task, due to the unusual nature of producing DNA from RNA.

Because reverse transcription lacks the usual proofreading of DNA replication, this kind of virus mutates very often. This enables the virus to grow resistant to antiviral pharmaceuticals quickly, and impedes, for example, the development of an effective vaccine against HIV.

Retrovirus genomes commonly contain these three genes, among others, that encode for proteins that can be found in the mature virus:

group-specific antigen (gag) codes for core and structural proteins of the virus;
polymerase (pol) codes for reverse transcriptase, protease and integrase; and,
envelope (env) codes for the retroviral coat proteins.

Thus far, four human retroviruses — HTLV 1 and 2, in conjunction with HIV 1 and 2 have been found to attack Helper T cells.

Studies of retroviruses led to the first demonstrated synthesis of DNA from RNA templates, a fundamental mode for transferring genetic material that occurs in both eukaryotes and prokaryotes. It has been speculated that the RNA to DNA transcription processes used by retroviruses may have first caused DNA to be used as genetic material. In this model, cellular organisms adopted the more chemically stable DNA when retroviruses evolved to create DNA from the RNA templates.

The following genera are included here:

Genus Alpharetrovirus; type species: Avian leucosis virus
Genus Betaretrovirus; type species: Mouse mammary tumour virus
Genus Gammaretrovirus; type species: Murine leukemia virus; others include Feline leukemia virus
Genus Deltaretrovirus; type species: Bovine leukemia virus; others include the cancer-causing Human T-lymphotropic virus
Genus Epsilonretrovirus; type species: Walleye dermal sarcoma virus
Genus Lentivirus; type species: Human immunodeficiency virus 1; others include Simian, Feline immunodeficiency viruses
Genus Spumavirus; type species: Chimpanzee foamy virus

These were previously divided into three subfamilies (Oncovirinae, Lentivirinae, and Spumavirinae), but with our current knowledge of retroviruses, this is no longer appropriate. Endogenous retroviruses are not formally included in this classification system, and are broadly classified into three classes, on the basis of relatedness to exogenous genera: Class I are most similar to the gammaretroviruses, Class II to the betaretroviruses and alpharetroviruses, and Class III to the spumaviruses.

[edit] In Fiction

In science fiction, many plots feature a retrovirus which mutates cells it infects. Examples of this include;

The whole Resident Evil series (the T-Virus)
The Doom movie
The Stargate Atlantis (ATA gene therapy, the anti-Wraith retrovirus)
In Parasite Eve 2 a retrovirus is used to make NMC, the enemies of the game.
The books Darwin's Radio and Darwin's Children by Greg Bear
The PlayStation 2 RPG series Xenosaga (The U.R.T.V.s (U-DO Retrovirus), genetically modified human children made to act as a retrovirus to the entity known as "U-DO".)
The comic book Supreme Power chronicles the arrival of an extraterrestrial whose ship contains a retrovirus that sprays over the Earth as it enters orbit, thus altering the DNA of a few selected individuals to bestow superpowers upon them.
In Metal Gear Solid, the programmable virus FOXDIE is a retrovirus.
In The X-Files
Nick Sagan's Idlewild and its sequels are centered around a retroviral plague.

In one Simpson's episode Professor Frink warns the Simpsons to be careful of retroviruses when they are inside Mr. Burns. "Man are they retro, but seriously touch one and you're dead."