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This article is about a molecular line notation. For other uses, see Dutch Sign Language.

sybyl line notation <tr><th style="white-space: nowrap;">File extension:</th><td>.sln</td></tr><tr><th style="white-space: nowrap;">Type of format:</th><td>chemical file format</td></tr>

The SYBYL line notation or SLN is a specification for unambiguously describing the structure of chemical molecules using short ASCII strings. SLN differs from SMILES in several significant ways. SLN can specify molecules, molecular queries, and reactions in a single line notation whereas SMILES handles these through language extensions. SLN has support for relative stereochemistry, it can distinguish mixtures of enantiomers from pure molecules with pure but unresolved stereochemistry.

[edit] Examples

Elemental atoms are specified by the standard abbreviation of the chemical elements. Atom attributes follow the atom name in square brackets. C[I=14] indicates carbon-14 isotope. Hydrogens are normally explicitly specified as a shorthand, CH4 is the SLN for methane. In addition to elemental atoms SLN supports the specification of wild card atoms: Any (match any atom), and Hev (match any heavy atom). It also has an extensive Markush syntax for specifying combinatorial libraries and RGROUP queries.

[edit] See also

• Simplified molecular input line entry specification (SMILES notation)

[edit] References

• Sheila Ash, Malcolm A. Cline, R. Webster Homer, Tad Hurst, and Gregory B. Smith, SYBYL Line Notation (SLN): A Versatile Language for Chemical Structure Representation, J. Chem. Inf. Comput. Sci., 1997, 37, 71-79. DOI:10.1021/ci960109j