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Securin

<tr><td bgcolor=#e7dcc3 width=85>Gene code:</td>

   <td style="border-top:2px solid #e7dcc3" width=220>[1] #ID : AAB00106.1</td></tr>

<tr><td bgcolor=#e7dcc3 width=85>Structure:</td>

   <td style="border-top:1px solid #e7dcc3" width=220>Unknown</td></tr>

<tr><td bgcolor=#e7dcc3 width=85>Recent publications:</td>

   <td style="border-top:1px solid #e7dcc3" width=220>[2]

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).,
[3] Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.,
[4] Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.</td></tr> <tr><td bgcolor=#e7dcc3 width=85>Taxa expressing:</td>

   <td style="border-top:1px solid #e7dcc3" width=220>Eukaryotes</td></tr>

<tr><td bgcolor=#e7dcc3 width=85>Cell types:</td>

   <td style="border-top:1px solid #e7dcc3" width=220>all</td></tr>

<tr><td bgcolor=#e7dcc3 width=85>Subcellular localization:</td>

   <td style="border-top:1px solid #e7dcc3" width=220>Nucleus</td></tr>

</table>

Securin is a protein involved in anaphase triggering. It has two identified roles; the first one is to help the transport of separase to the nucleus and the second role is to inhibit the catalytic activity of separase. Securin is ubiquitinated by the Anaphase Promoting Complex (APC), and then degraded by the Proteasome, releasing separase.