Submandibular gland

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The paired submandibular glands (or submaxillary glands) are salivary glands located beneath the floor of the mouth. In humans, they account for 70% of the salivary volume. Their secretions, like the secretions of other salivary glands, are regulated directly by the parasympathetic nervous system and indirectly by the sympathetic nervous system.

[edit] Anatomy

Lying superior to the digastric muscles, each submandibular gland is divided into superficial and deep lobes, which are separated by the mylohyoid muscle. Lobes contain smaller lobules, which contain adenomeres, the secretory units of the gland. Each adenomere contains one or more acini, or alveoli, which are small clusters of cells that secrete their products into a duct. The acini of each adenomere may be predominantly composed of either serous or mucous cells. Some mucous adenomeres are also be capped with a serous demilune, a layer of lysozyme-secreting serous cells resembling a half moon. Secretions are delivered into Wharton's ducts, which open into two papillae on either side of the lingual frenulum.

Like other exocrine glands, the submandibular gland can be classified by the microscopic anatomy of its secretory cells and how they are arranged. Because the glands are branched, and because the tubules forming the branches contain secretory cells, submandibular glands are classified as branched tubuloacinar glands. Further, because the secretory cells are of both serous and mucous types, the submandibular gland is a mixed gland.

[edit] Functions

The secretory cells of the submandibular gland have distinct functions. In particular, the serous cells produce salivary amylase, which aids in the break down of starches in the mouth. Mucous cells secrete mucin which aids in the lubrication of the food bolus as it travels through the oesophagus. The mucous cells are the most active and therefore the major product of the submandibular glands is viscous saliva.

The submandibular gland's highly active acini account for approximately 70% of salivary volume. The parotid and sublingual glands account for the remaining 30%.

[edit] Innervation

Parasympathetic innervation to the submandibular glands is provided by the superior salivatory nucleus via the chorda tympani, a branch of the facial nerve that synapses in the submandibular ganglion. Increased parasympathetic activity promotes the secretion of saliva.

Although it does not receive direct sympathetic innervation, the sympathetic nervous system does indirectly regulate submandibular secretions through vasoconstriction of the arteries that supply the submandibular gland. Increased sympathetic activity reduces glandular bloodflow, thereby decreasing salivary secretions.

[edit] Pathology

The submandibular gland accounts for 80% of all salivary duct calculi, possibly due to the different nature of the saliva that it produces and that its duct is up-sloping.

[edit] Additional images

Human submaxillary gland. At the right is a group of mucous alveoli, at the left a group of serous alveoli.

[edit] References

• Douglas F. Paulsen (2000). Histology and cell biology, 4th edition, Stamford, Conn: Lange Medical Books/McGraw Hill. ISBN 0-8385-0593-7.

[edit] External links

• Histology at usc.edu
• Dictionary at eMedicine submandibular+glandde:Glandula submandibularis

it:Ghiandola sottomandibolare