Succinyl-CoA

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Succinyl-CoA (coenzyme A is grey)

Succinyl-Coenzyme A, generally abbreviated as Succinyl-CoA is a combination of succinic acid and coenzyme A.

1 Source
2 Fate
3 Formation
4 See also

[edit] Source

It is an important intermediate in the citric acid cycle, where it is synthetised from α-Ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added.

It is also synthetised from propionyl CoA, the odd numbered fatty acid which cannot undergoes beta-oxidation. Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerised to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle and can be readily incorporated there.

[edit] Fate

It is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (succinate thiokinase).

Another fate of succinyl-CoA is porphyrin synthesis, where succinyl-CoA and glycine are combined by ALA synthase to form δ-aminolevulinic acid (dALA).

[edit] Formation

Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by methylmalonyl CoA Mutase. This reaction, which requires vitamin B12 to occur, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.

[edit] See also

v • d • e</span>

Citric Acid Cycle Metabolic Pathway

Malate

Image:Oxaloacetate wpmp.png

Image:S-malate wpmp.png

Image:Fumarate wpmp.png

Image:Succinate wpmp.png

Image:Succinyl-CoA wpmp.png

Image:Biochem reaction arrow reverse NNYY horiz med.png

Image:Biochem reaction arrow reverse NNYN horiz med.png

Image:Biochem reaction arrow reverse NNYY horiz med.png

Acetyl CoA

NADH + H⁺

NAD⁺

H₂O

FADH₂

FAD

CoA + ATP

P_i + ADP

Image:Acetyl co-A wpmp.png

H₂O

Image:Biochem reaction arrow special 1.png

Image:Biochem reaction arrow special 2.png

NADH + H⁺ + CO₂

CoA

NAD⁺

Image:Citrate wpmp.png

H₂O

Image:Cis-Aconitate wpmp.png

H₂O

Image:Threo-Ds-isocitrate wpmp.png

NADP⁺

NADPH + H⁺

Image:Oxalosuccinate wpmp.png

CO₂

Image:2-oxoglutarate wpmp.png

Image:Biochem reaction arrow foward NYNN horiz med.png

Image:Biochem reaction arrow foward YNNN horiz med.png

Image:Biochem reaction arrow foward YYNN horiz med.png

Image:Biochem reaction arrow foward NYNN horiz med.png

Citrate

cis-Aconitate

Isocitrate

Oxalosuccinate

Alpha-ketoglutarate

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