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Titin
Identifiers
Symbol(s)	TTN
Entrez	7273
OMIM	188840
RefSeq	NM_133378
UniProt	Q8WZ42
Other data
Locus	Chr. 2 q31

Image:SlidingMyofibril.svg Titin, also known as connectin, (UniProt name: Q10466_HUMAN; accession number: Q10466) is a protein that is important in the contraction of striated muscle tissues. Titin connects the Z line to the M line in the sarcomere. The protein limits the range of motion of the sarcomere in tension, thus contributing to the passive stiffness of muscle. Variations in the sequence of titin between different types of muscle (e.g. cardiac or skeletal) has been correlated with differences in the mechanical properties of the muscles.<ref>Labeit S, Kolmerer B (1995). "Titins: giant proteins in charge of muscle ultrastructure and elasticity". Science 270: 293-6.</ref>

Titin is the largest known protein, consisting of 26,926 amino acids. The molecular weight of the mature protein is approximately 2,993,451.39 Da, and it has a theoretical pI of 6.35 [1]. The protein's chemical formula is C₁₃₂₉₈₃H₂₁₁₈₆₁N₃₆₁₄₉O₄₀₈₈₃S₆₉₃. It has a theoretical instability index (II) of 39.69, indicating that it would be stable in a test tube. The protein's in vivo half-life, the time it takes for half of the amount of protein in a cell to disappear after its synthesis in the cell, is predicted to be approximately 30 hours (in mammalian reticulocytes).<ref>Swiss-Prot Protein knowledgebase, main entry. Retrieved on 2006-05-04.</ref>

As the largest known protein, titin has the longest full chemical name. The full chemical name, containing 189,819 letters, is sometimes claimed to be the longest word in the English language.

[edit] References

[edit] See also

• Protein
• Amino acid
• Longest word in the English language
• Methionylalanylthreonyl...leucine
• Acetylseryltyrosylseryliso...serine

Muscle tissue v • d • e</div>

skeletal muscle/general: epimysium, fascicle, perimysium, endomysium, muscle fiber, myofibril sarcomere (a, i, and h bands; z and m lines), myofilaments (thin filament/actin, thick filament/myosin, elastic filament/titin), tropomyosin, troponin neuromuscular junction, intrafusal muscle fibers, extrafusal muscle fiber, motor unit, muscle spindle, sliding filament mechanism myoblast, satellite cells, sarcoplasm, sarcolemma, sarcoplasmic reticulum, T-tubule cardiac muscle: myocardium, intercalated disc smooth muscle: calmodulin, vascular smooth muscle

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