Tryptophan hydroxylase
From Wikipedia, the free encyclopedia
Tryptophan hydroxylase (TPH or TH) is an enzyme involved in the synthesis of the neurotransmitter serotonin. It is responsible for addition of the -OH group to the 5 position to form the amino acid 5-hydroxytryptophan (5-HTP), which is then converted to serotonin by decarboxylation. Analogous to phenylalanine hydroxylase and tyrosine hydroxylase, this enzyme uses tetrahydrobiopterin as a co-substrate. [1]
