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Yolk sac

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Yolk sac
Human embryo of 2.6 mm.
Human embryo from thirty-one to thirty-four days
Gray's subject #11 54
MeSH Yolk+Sac
Dorlands/Elsevier s_01/12716805

The yolk sac is the first element seen in the gestational sac during pregnancy, usually at 5 weeks gestation.

It is a critical landmark, identifying a true gestation sac.

It is quite echogenic (light) to ultrasound, and reliably seen early.

Contents

[edit] In mice

In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes.

[edit] In humans

The yolk-sac is situated on the ventral aspect of the embryo; it is lined by endoderm, outside of which is a layer of mesoderm.

It is filled with fluid, the vitelline fluid, which possibly may be utilized for the nourishment of the embryo during the earlier stages of its existence.

Blood is conveyed to the wall of the sac by the primitive aortæ, and after circulating through a wide-meshed capillary plexus, is returned by the vitelline veins to the tubular heart of the embryo. This constitutes the vitelline circulation, and by means of it nutritive material is absorbed from the yolk-sac and conveyed to the embryo.

At the end of the fourth week the yolk-sac presents the appearance of a small pear-shaped vesicle (umbilical vesicle) opening into the digestive tube by a long narrow tube, the vitelline duct.

The vesicle can be seen in the after-birth as a small, somewhat oval-shaped body whose diameter varies from 1 mm. to 5 mm.; it is situated between the amnion and the chorion and may lie on or at a varying distance from the placenta.

As a rule the duct undergoes complete obliteration during the seventh week, but in about three per cent. of cases its proximal part persists as a diverticulum from the small intestine, Meckel’s diverticulum, which is situated about three or four feet above the ileocolic junction, and may be attached by a fibrous cord to the abdominal wall at the umbilicus.

Sometimes a narrowing of the lumen of the ileum is seen opposite the site of attachment of the duct.

[edit] Additional images

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.

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Mammalian development of embryo and development and fetus (some dates are approximate - see Carnegie stages) - edit - discuss

Week 1: Zygote | Morula | Blastula/Blastomere/Blastosphere | Archenteron/Primitive streak | Blastopore | Allantois | Trophoblast (Cytotrophoblast | Syncytiotrophoblast | Gestational sac)

Week 2: Yolk sac | Vitelline duct | Bilaminar disc

Week 3: Hensen's node | Gastrula/Gastrulation | Trilaminar embryo Branchial arch (1st) | Branchial pouch | Meckel's cartilage | Somite/Somitomere | Germ layer (Ectoderm, Endoderm, Mesoderm, Chordamesoderm, Paraxial mesoderm, Intermediate mesoderm, Lateral plate mesoderm)

Histogenesis and Organogenesis

Circulatory system: Primitive atrium | Primitive ventricle | Bulbus cordis | Truncus arteriosus | Ostium primum | Foramen ovale | Ductus venosus | Ductus arteriosus | Aortic arches | Septum primum | Septum secundum | Cardinal veins

Nervous system: Neural development/Neurulation | Neurula | Neural folds | Neural groove | Neural tube | Neural crest | Neuromere (Rhombomere) | Notochord | Optic vesicles | Optic stalk | Optic cup

Digestive system: Foregut | Midgut | Hindgut | Proctodeum | Rathke's pouch | Septum transversum

Urinary/Reproductive system: Urogenital folds | Urethral groove | Urogenital sinus | Kidney development (Pronephros | Mesonephros | Ureteric bud | Metanephric blastema) | Fetal genital development (Wolffian duct | Müllerian duct | Gubernaculum | Labioscrotal folds)

Glands: Thyroglossal duct

Uterine support: Placenta | Umbilical cord (Umbilical artery, Umbilical vein, Wharton's jelly) | Amniotic sac (Amnion, Chorion)

Limb development: Limb bud | Apical Ectodermal Ridge/AER

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