Entrez

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Image:Entrez.svg The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. NCBI is part of the National Library of Medicine (NLM), itself a department of the National Institutes of Health (NIH) of the United States government.

1 Searching
2 GenBank
3 NLM Catalog
4 See also
5 External link

[edit] Searching

Entrez is a powerful federated search engine, or web portal that allows users to search a multiple of discrete health sciences databases, maintained by the National Center for Biotechnology Information with a single query string and user interface. NCBI includes the following databases:

PubMed: biomedical literature citations and abstracts, including Medline - articles from (mainly medical) journals, often including abstracts. Links to PubMed Central and other full-text resources are provided to articles from the 1990s.
PubMed Central: free, full text journal articles
Site Search: NCBI web and FTP web sites
Books: online books
OMIM: online Mendelian Inheritance in Man
OMIA: online Mendelian Inheritance in Animals
Nucleotide: sequence database (GenBank)
Protein: sequence database
Genome: whole genome sequences and Mapping
Structure: three-dimensional macromolecular structures
Taxonomy: organisms in GenBank Taxonomy
SNP: single nucleotide polymorphism
Gene: gene-centered information
HomoloGene: eukaryotic homology groups
PubChem Compound: unique small molecule chemical structures
PubChem Substance: deposited chemical substance records
Genome Project: genome project information
UniGene: gene-oriented clusters of transcript sequences
CDD: conserved protein domain database
3D Domains: domains from Entrez Structure
UniSTS: markers and mapping data
PopSet: population study data sets (epidemiology)
GEO Profiles: expression and molecular abundance profiles
GEO DataSets: experimental sets of GEO data
Cancer Chromosomes: cytogenetic databases
PubChem BioAssay: bioactivity screens of chemical substances
GENSAT: gene expression atlas of mouse central nervous system
Probe: sequence-specific reagents

The Entrez system can provide views of gene and protein sequences and chromosome maps. Entrez can efficiently retrieve related sequences, structures, and references. Some textbooks are also available online through the Entrez system. Entrez Global Query is an integrated search and retrieval system that provides access to all databases simultaneously.

[edit] GenBank

Main article: GenBank

The NCBI has had responsibility for making available the GenBank DNA sequence database since 1992. GenBank coordinates with individual laboratories and other sequence databases such as those of the European Molecular Biology Laboratory and the DNA Database of Japan.

Since 1992, NCBI has grown to provide other databases in addition to GenBank. NCBI provides Online Mendelian Inheritance in Man, the Molecular Modeling Database (3D protein structures), the Unique Human Gene Sequence Collection, a Gene Map of the Human genome, a Taxonomy Browser, and coordinates with the National Cancer Institute to provide the Cancer Genome Anatomy Project.

The NCBI has software tools that are available by WWW browsing or by FTP. For example, BLAST is a sequence similarity searching program. BLAST can do sequence comparisons against the GenBank DNA database in less than 15 seconds.

[edit] NLM Catalog

The NLM Catalog provides access to NLM bibliographic data for over 1.2 million journals, books, audiovisuals, computer software, electronic resources, and other materials via the NCBI Entrez retrieval system. Updated every weekday, the NLM Catalog is an alternative search interface to the bibliographic records resident in LocatorPlus.